Sulbutiamine is a synthetic version of thiamine, otherwise known as vitamin B1. This unique chemical compound was first developed by the Japanese with the express purpose of reversing the effects of chronic B1 deficiency.

A lack of vitamin B1 in your system can lead to acute issues concerning memory, the length of your attention span, your alertness to conditions around you, and even the quality of your overall mood. A profound sense of depression can develop in people who suffer from a lack of B1 in their diet, and this only heightens the dangers that can develop from lack of energy and the proper amount of exercise.

However, the benefits of sulbutiamine appear to exist even when taken by healthy individuals, who aren’t deficient in B1.

Supplementing with sulbutiamine has also been demonstrated to have profound nootropic effects resulting in a boost of energy, cognition, and mood.

Benefits and Effects

The most well-known and remarked upon benefit that sulbutiamine provides is its ability to improve the memory of people who take it regularly.

People who have taken sulbutiamine on a regular basis have noted a marked increase in their ability to take in and retain information. In other words, they have noticed an improvement in both their short and long-term memory skills. While the exact effects of the process are still being researched, scientists have managed to come up with a working thesis of why this is so.

It seems that the beneficial effects of sulbutiamine are due to the enhancing effect that this substance has on the neurons of the brain, specifically in their basic transmission and communication abilities. This enhancement, in turn, is due to the effects that sulbutiamine produces upon substances that control these vital brain activities, namely glutamate, dopamine, and acetylcholine.

Increase Alertness and Energy Levels

The specific effect that sulbutiamine has on dopamine levels in the human brain is a source of ongoing scientific and medical research. It seems that sulbutiamine stimulates the ability of users to focus their concentration on specific tasks, while simultaneously enhancing their ability to perceive and react productively to events that are occurring around them. For this reason, many users have reported that sulbutiamine is an excellent study aid.

Improve Mood and Reduce Anxiety

Sulbutiamine has also been shown, at least anecdotally, to have a positive effect on a user’s general mood, particularly when it comes to reducing anxiety. Again, this is due to the ability of sulbutiamine to stimulate the levels of dopamine in the brain. It seems that the increased ability to focus and concentrate on one’s tasks and general surroundings leads naturally to an improvement in mood.

As a result of this increased focus and concentration, it follows that people who regularly take sulbutiamine tend to report radically decreased levels of general anxiety and nervousness, particularly in social situations that were formerly a source of great misapprehension and fear. In fact, the ability of sulbutiamine to relieve stress and anxiety in this regard forms yet another portion of the ongoing scientific and medical research surrounding this substance.

How it Works

Sulbutiamine has long been classified as a synthetic version of thiamine, precisely because it emulates the positive effects that are associated with vitamin B1. Perhaps the chief reason that many people prefer sulbutiamine to genuine thiamine is that it crosses the blood-brain barrier much more easily, giving rise more quickly to even stronger results.

Once the blood-brain barrier has been crossed, sulbutiamine has an immediate effect on the cholinergic, glutamatergic, and dopamine receptors that influence such vital activities as concentration, memory, and mood. Because sulbutiamine is extremely fat soluble, it circulates widely and rapidly throughout the brain and body, making its presence known very quickly by the scope and magnitude of its resulting effects.


A precise definition of the correct dosage of sulbutiamine is practically impossible to offer on a generalized basis. How much or how little (or any at all) of this substance you need to realize its positive results will depend on a number of factors. These factors include your natural biochemistry and metabolism, as well as your general level of health and “tolerance” for prescribed medications.

In addition, other supplements you may be taking at the moment might have a positive or negative effect on just how effective sulbutiamine is for you. Before you even consider taking sulbutiamine, you should consult with a doctor to determine whether this supplement is right for you.

The average recommended dosage of sulbutiamine will normally vary between a level of 400 and 800 mg, not to be exceeded within a period of 24 hours. Once you have ascertained the dosage level that is right for you, you can begin taking the supplement immediately.

Whether you take sulbutiamine in bulk or pill form, you should note that sulbutiamine is fat soluble, rather than water soluble. This means that, although sulbutiamine works most rapidly when taken with a liquid, it is not capable of being mixed with the usual juices (apple, orange, and the like) that are associated with the consumption of health supplements and instead should be taken with a fat source such as oil or milk.

If you do decide to take sulbutiamine it is important to note that tolerance can set in as quickly with its positive effects beginning to diminish sometimes in less than a week. That is why it is recommended to either cycle sulbutiamine or to save it specifically for days that can use that extra boost.


If you’ve read this far, you may well be wondering what supplements sulbutiamine best stacks with, in order to achieve the maximum positive effects.

Sulbutiamine + Huperzine A + Choline Stack

While one’s mileage may vary, a “starter’s stack,” consisting of sulbutiamine, Huperzine A and a choline source such as Alpha GPC may be a good start.

1-2x per day

Huperzine A is a supplement that is derived from the common herb known as Irish Moss. It works by slowing down the decomposition of acetylcholine. By ensuring an optimal level of this vital organic molecule, huperzine A helps to increase your ability to focus and concentrate. Meanwhile, choline works in concert with Huperzine A and sulbutiamine to ensure maximum memory power and capacity for concentrated attention. When it comes to pure concentrated choline content, Alpha GPC has the edge, as it contains 40 percent by weight. However, for individuals who are also seeking a supplement to augment their capacity for motivation, as well as provide relief from anxiety, citicoline may be the better choice, due to its effect on the dopamine receptors in the brain.

Sulbutiamine + Aniracetam + Choline Stack

Sulbutiamine also stacks well with the racetam class of nootropics. Among the racetams, stacking sulbutiamine with aniracetam is a common choice due to aniracetam’s similar effects on cognition and mood, really enhancing overall effects.

1-2x per day

Side Effects

One of the primary sources of the continuing appeal of sulbutiamine is its relative lack of potentially harmful side effects. Perhaps the most common side effect is an increase in anxiety and irritability. There have been a few reports of nausea however these reports are minimal. However, it should also quickly be added that these particular side effects tend to appear after much larger than normally recommended doses of the supplement have been ingested.

As can perhaps be surmised after reading the previous sentence, it is also true that some users of sulbutiamine do tend to develop a tolerance for the supplement. This increased tolerance can lead to users feeling the need to use higher dosages to continue experiencing its benefits.

However, despite this evidence and the strong recommendation that users who notice themselves gaining a higher tolerance for sulbutiamine stop taking it, there is no general consensus on the part of medical experts as to whether the supplement is habit forming. As noted above, however, it is recommended that you discontinue using it if you do notice any increase in your general tolerance.

Where to Buy

Sulbutiamine is available in two distinct forms: capsules and bulk powder. According to your preference and budget, you may choose either of these two. Buying the supplement in loose bulk form is much cheaper than capsules, but if you find capsules more convenient the option exists.

We recommend Double Wood Sulbutiamine from Amazon.

Alternatively, we recommend purchasing sulbutiamine and any other nootropics from as they are a reputable source for supplements.

Closing Thoughts

As has been demonstrated, sulbutiamine is a powerful and proactive supplement that is steadily increasing in popularity and usage. While much of the claims made on its behalf have yet to be verified via the proper scientific and medical research, many nootropic users all over the world swear by sulbutiamine’s positive effects.

Planning to start a new supplementation regimen? See our medical disclaimer.