Pramiracetam is one of the most interesting nootropics available, offering the greatest potency of any of the racetam-class supplements.
Its unique action optimizes overall brain function, improving memory, learning capacity, focus, and even sensory perception.
It works well on its own and can be an invaluable addition to other nootropics, enhancing and extending their effects.
Rapidly becoming a favorite with students, writers, and anyone who is interested in maximizing their mental abilities, pramiracetam is new to many people but is starting to get well-earned recognition as an outstanding nootropic.
Pramiracetam is a synthetic derivative of piracetam, discovered and developed by Parke-Davis in the 1970s. It is a particularly potent supplement, estimated to be from 5-30x more potent than piracetam.
It is sold in Europe under the brand names Neupramir, Pramistar, and Remen and is prescribed there for treatment of dyslexia, ADHD, dementia and memory problems caused by Alzheimer’s disease and other neurological conditions.
It was patented in the US in 1979 but is not approved by the USFDA for any particular use. However, it has been extensively studied as a potential treatment for cognitive problems and memory loss associated with Alzheimer’s disease and brain injury. It is also being studied as a treatment for a variety of central nervous system disorders.
Benefits and Effects
Pramiracetam optimizes brain performance and provides marked cognitive improvement, particularly regarding memory formation and retrieval.
Because it often creates a noticeable feeling of focus along with a certain amount of emotional blunting, it is often compared to Ritalin. Some of the most widely-recognized benefits of pramiracetam are as follows:
- Improved Memory – Because it stimulates the hippocampus, the part of the brain primarily responsible for the creation of new memories, pramiracetam is known as a very powerful memory enhancer. Most users report significant improvement in memory formation and speed of recall, a claim that has been corroborated by animal studies.
- Expanded Learning Capacity – Users report that pramiracetam makes learning faster, easier, and more enjoyable. This can be explained at least in part by pramiracetam’s facilitation of greater neuroplasticity.
- Mental Alertness and Clarity – Typically users report that taking pramiracetam gives them strong feelings of mental alertness, focus, rapid idea formation, and clear thinking.
- Social Fluency – Many users say that taking pramiracetam helps them enjoy and fully participate in social situations, a benefit that is likely related to the supplement’s overall brain function optimization but could also be somewhat related to its emotional blunting effects, which may reduce social anxiety.
- Improved Sensory Perception – Users often report enhanced or improved sensory perceptions, including amplified and richer sound and clearer and more vivid visual perception with greater color contrast.
- Memory Repair – In limited clinical trials, pramiracetam has been shown to be an effective treatment for memory loss and other cognitive problems caused by brain injuries. It is also one of the various nootropics that have been tested in the US as a possible treatment of memory loss related to Alzheimer’s disease and other neurological disorders. One study has even shown it to be capable of reversing chemically induced amnesia in healthy volunteers from 18-65 years of age.
How it Works
Like most nootropics, pramiracetam affects the release of neurotransmitters, brain chemicals that transmit signals from one nerve cell to another. But pramiracetam does it indirectly, in a manner somewhat different from the usual actions of racetam supplements, and it stimulates the brain in other ways as well.
Unlike piracetam, Noopept, and many other popular nootropics, pramiracetam is fat soluble rather than water soluble, which means it is absorbed into the bloodstream via fatty acids. It reaches peak concentrations and maximum bioavailability relatively quickly, generally within 30 minutes, and it has a moderately long half-life of 4-6 hours.
Most racetams work by directly stimulating specific neurotransmitter receptor sites and thus increasing production and release of specific neurotransmitters, but pramiracetam doesn’t directly result in changes in neurochemical levels, and it doesn’t appear to have an affinity for any major neurotransmitter.
Its primary direct action is a significant increase in high-affinity choline uptake in the hippocampus, the part of the brain crucial to the formation of long-term memories.
Choline is a precursor of acetylcholine, a neurotransmitter profoundly involved in cognitive processes including learning speed, memory, and concentration.
By stimulating choline uptake, pramiracetam indirectly modulates the release of acetylcholine and stimulates increased activity in the hippocampus. Because this part of the brain is essential to memory function, the general stimulation that pramiracetam creates can improve both the formation of new memories and the retention of reference or long-term memories. The increased activity in the hippocampus also increases cerebral blood flow, which enhances alertness and improves cognitive abilities in general.
Pramiracetam may have other mechanisms of action as well. Researchers have hypothesized that in addition to its effect on the brain, pramiracetam acts in peripheral sites outside the brain that rely on the adrenal glands. Animal studies suggest that pramiracetam may also increase or restore brain membrane fluidity, which facilitates cell signaling.
Unlike many other racetam class nootropics, pramiracetam doesn’t appear to actively alter either wakefulness or emotional states. This can be explained by pramiracetam’s limited influence on the production and release of the neurotransmitters that have the greatest effect on mood and anxiety levels such as serotonin, GABA, and dopamine.
Though pramiracetam is well tolerated even at high dosages, individual reactions vary and it’s important for each user to find their own optimal dosage to maximize benefits.
Due to the lack of sufficient scientific studies, recommendations on the most effective daily dose vary considerably. Of the various studies done on testing the effectiveness of pramiracetam, they concluded that a total daily intake of 1200 mg was optimal, divided into two or three doses per day. This is likely a good starting point and on an individual level should be adjusted to find what works best for you.
While there are very few adverse side effects associated with this supplement, it is always wise to start with the lowest effective dose and increase the dose gradually as needed.
One notable aspect of consuming the powder form of pramiracetam is that it has a very pungent flavor that most people find extremely unpleasant. Many users prefer to either purchase this supplement in capsule form or to make their own capsules.
The fact that it is fat rather than water soluble means that mixing the powder with water is difficult. Rather than dissolving, it will simply float on the surface. Some users report dissolving their dose of pramiracetam powder with a small amount of oil which may also enhance absorption and bioavailability.
Pramiracetam works well on its own, but one of its most interesting aspects is that it appears to be a powerful potentiator for other nootropics, increasing their effectiveness.
It is a particularly effective potentiator for other racetams, making it a natural addition to most nootropic stacks.
Adding a choline supplement to a pramiracetam stack could have multiple benefits. Not only can it enhance pramiracetam’s effects, but it can also prevent headaches, which are the most commonly reported side effect.
Because pramiracetam has such potent effects, it is advisable to use it on its own for a trial period before combining it with other nootropics.
Pramiracetam and Oxiracetam Stack
Pramiracetam and Aniracetam Stack
Stacking pramiracetam with a powerful anti-anxiety agent like aniracetam can give users heightened focus and concentration while improving mood and reducing feelings of mental strain and anxiety. Some users say this stack promotes social fluency and improves their public performance ability.
Pramiracetam is usually well tolerated even at high dosages, and very few adverse side effects have been documented.
The most commonly reported side effect is a headache, which can usually be prevented by taking it with a choline supplement.
Less common side effects, including gastrointestinal distress and feelings of nervousness or agitation, are generally associated with high dosage and can, therefore, be avoided by reducing dosage.
Pramiracetam is non-addictive, and no significant adverse effects of long-term use have been documented. In fact, there is evidence that this supplement may even promote brain health and to some extent restore function in aging brains.
Where to Buy
It isn’t usually possible to find pramiracetam in retail stores, but it is available from specialty online stores that carry nootropics. It is important to stick to vendors that you can trust.
We recommend PureNootropics.net for ordering pramiracetam and other nootropics. All their products are tested by 3rd party laboratories for purity so you can rest assured that you are dealing with a company that stands by its products.
Pramiracetam is a very powerful nootropic that is relatively new to many users but is rapidly growing in popularity.
Because it’s more complicated to synthesize it’s higher in price than other racetams; some users find the cost problematic, though the high potency of the supplement also means that lower dosages are needed.
Users also have mixed reactions to the Ritalin-like emotional blunting effect of the supplement. For some people, it creates a welcome objectivity and relief from social anxiety, while others say it makes them feel dissociated.
Pramiracetam is widely accepted as an excellent nootropic, measurably improving memory formation and retention, learning speed, and general mental clarity, acuity, and focus. It’s generally considered to be a valuable addition to other nootropic stacks, in many cases increasing both the potency of the other stacked supplements and the duration of their effects.
Pramiracetam is safe, potent, fast acting and relatively long lasting. It has been found to be a valuable nootropic supplement for students, writers, researchers, or anyone who wants better memory, faster recall, and greater mental focus, clarity, and speed of thought.
Planning to start a new supplementation regimen? See our medical disclaimer.