Summary

Noopept shares similar cellular mechanisms to the popular racetam family of nootropics that are known for their benefits on cognitive ability as well as their neuroprotective properties. What makes Noopept a particularly unique nootropic is that its effects are felt almost immediately after ingestion.

Many nootropics can take days, weeks, or even months, to experience their benefits, however, Noopept has fast-acting acute effects. Another nootropic that compares to Noopept’s immediate effects is phenylpiracetam.

Currently, Noopept is being prescribed and distributed in Russia and its surrounding countries for its nootropic properties. Its popularity has drastically increased and is now distributed worldwide.

Noopept is often compared to piracetam and aniracetam. It works via a similar mechanism as piracetam but is estimated to be 1,000 times more potent. Its impressive potency doesn’t imply that its effect is more profound; it simply attunes itself better to the brain’s receptors, and as a result, Noopept can be taken in relatively smaller doses to produce similar effects as that of piracetam.

Noopept is also very inexpensive when compared to other nootropics because of how potent it is per milligram. Its effectiveness and affordable cost per dose have made it a favorite among the nootropic community.

Benefits and Effects

To have a better understanding of Noopept, here is a breakdown of its many benefits.

Memory and Learning

Noopept’s most desired effect is that it may enhance memory and improve the learning process.

Noopept, like piracetam, assists with memory formation, but with additional benefits including memory consolidation and memory retrieval.‍[1] Noopept facilitates the proper management of all forms of stimuli as they are processed by the brain, which allows for better memory retrieval. Signals being processed by the senses are more streamlined as they are transported into our brains in the form of memory.

Note that Noopept’s positive effects on memory and learning in the various clinical studies have been primarily done on models of cognitive decline or brain damage. However, there is one study that demonstrated improved spatial learning in healthy adult rodents.‍[2]

Evidence of cognitive enhancing effects of Noopept on healthy humans is limited to anecdotal reports.

Increased levels of NGF and BDNF

In animal studies, Noopept has shown that it stimulates the expression of NGF and BDNF in the hippocampus.‍[3]

NGF (Nerve Growth Factor) is a unique protein in the body that is involved in the growth, maintenance, and survival of nerve cells, including brain cells. NGF is also considered to be a key player in neurogenesis, your body’s ability to create new cells.

By increasing NGF levels in the brain, we support the mechanisms involved in neurogenesis which improves the performance of neural networks within the brain, allowing for new neural connections. The result means potentially improved mental abilities in virtually all areas of cognition.

BDNF (Brain-Derived Neurotrophic Factor) is another protein in the body that has a similar role to the NGF mentioned above. BDNF is considered one of the most important molecules involved in memory, playing a vital role in both short-term and long-term memory formation.‍[4]

Neuroprotective Properties

Various studies show that Noopept has high neuroprotective properties. It has demonstrated an antioxidant effect, anti-inflammatory action, and the ability to inhibit the neurotoxicity of excess calcium and glutamate, and to improve the blood flow.‍[5]‍[6]

Individuals dealing with cognitive impairment may benefit from a regular dosage of Noopept to prevent further dissociative cognitive functions.

Improves Communication between Brain Hemispheres

Both the right and left hemispheres of the brain have their own localized functions. There are nuances among these functions that enhance the way we think.

Noopept has demonstrated that it has a positive effect on the brain’s ability to communicate signals between the two hemispheres.‍[7] The improved hemisphere communication may explain why many people anecdotally claim that their quality of life had significantly improved by taking Noopept on a regular basis.

Anxiety Reduction

There is evidence that Noopept may be able to reduce anxiety.

In one animal study, rodents injected with Noopept appeared to have significantly lower their anxiety levels.‍[8]

In a human study, patients with mild cognitive disorders were given 10 mg of Noopept twice per day. All patients noted improvements in various parameters including anxiety reduction.‍[9]

How It Works

Users of Noopept report results of improved clarity, better memory, and focus. More studies are required to determine exactly how Noopept delivers its benefits to the human brain. Studies on animals have shown that Noopept increased alpha/beta1 activity in all brain areas, likely via the activation of NMDA receptors.‍[10]

In humans, based on observational, uncontrolled studies, Noopept demonstrated rehabilitative benefits to patients with mild cognitive disorders.‍[11] Currently, Noopept tablets are undergoing clinical assessment as a way of treating cognitive deficiency of post-traumatic origin and cerebrovascular cause. The brain benefits are derived from antioxidant action, anti-inflammatory properties, and the inhibition of toxicity with the elimination of excess glutamate and calcium. It was also observed that blood composition and flow were improved.

Taken orally, Noopept is absorbed by the digestive system and then readily crosses the blood-brain barrier.‍[12] When administered in the proper dosages, it is nearly completely used by the brain, and very little is wasted. Noopept targets glutamate receptor sites where it is believed to bind with the glutamate and inhibit breakdown. Glutamate, being one of the most powerful neurotransmitters, supports and expands cognitive functioning.

Noopept acts quickly once it is in the bloodstream, maximizing concentration after just 15 to 20 minutes.‍[13] Advocates of this nootropic report the flooding of clarity brought on by the immediate advantage of additional oxygen to the brain and improved glucose use. Many individuals report improved vision and sharper, more vibrant colors.‍[14]‍[15] Others have even reported enhanced hearing following just a short period of usage.‍[16]

Dosage

Due to its potency, the recommended dosage of Noopept is relatively small, typically 10 mg, taken twice per day after meals. Dosage may be increased to 30 mg per need if necessary.‍[17]

Since the body metabolizes Noopept rapidly, and it has a very short half-life in the human body, it may be preferable to take multiple small doses versus one large dose to extend Noopept’s acute effects.

When starting out with Noopept, we recommend a starting with the minimum effective dose, with careful observation, before increasing dosage. Each person should determine their own optimum dosage.

In powder form, Noopept is usually placed under the tongue or mixed with water and drunk. Effects are felt quickly after administration, as fast as within 15 minutes.

According to the dosing label that comes in the packet insert in Russia, it is recommended to take Noopept for 1.5-3 months and then, if necessary, to begin another cycle after a 1-month break.‍[18]

It is not recommended to take Noopept late in the evening as its energizing effects may interfere with sleep.

Stacking

Noopept can be taken alone but also does very well in nootropic stacks for additional synergistic benefits.

Noopept, Piracetam, and Choline Stack

Because Noopept delivers results similar to piracetam, stacking the two may result in synergistic benefits. The two supplements work on two different neurotransmitters, glutamate and acetylcholine, respectively. Gaining enhanced functionality of both transmitters could create a tremendous boost to a variety of cognitive processes. Furthermore, adding a choline supplement to the stack could make the piracetam more effective and help to hold off headaches reported by some initial-stage Noopept users.

1x-2x per day

Noopept, Aniracetam, Sulbutiamine Stack

Stacking Noopept with aniracetam and sulbutiamine would be a powerful stack that may not only boost cognition but also provide improvements to mood as well as reduce anxiety. These effects on mood and anxiety should also indirectly lead to improved creativity and mental performance due to the relaxed mindstate. Keep in mind sulbutiamine should be cycled to avoid building up a tolerance to it.

1x-2x per day

Noopept and Mind Lab Pro Stack

An easy and effective stack is to combine Noopept with a preformulated nootropic blend, such as Mind Lab Pro by Opti-Nutra which contains 11 all-natural research-backed ingredients. Mind Lab Pro can serve as an excellent foundation to your stack as it is designed to improve all aspects of memory, mental performance, mood and stress resistance, maintenance, and brain repair.

For a detailed overview of its ingredients and effects, refer to our Mind Lab Pro review.

1x-2x per day

Side Effects

The reported minor side effects include headaches, restlessness, dizziness, and irritability. These are most common when Noopept is taken in high doses.

Further evidence also suggests that Noopept can enhance the effects of stimulants such as amphetamines, so caution is advised. Noopept may also increase blood pressure in individuals with hypertension.‍[19]

Where to Buy

Noopept is not typically available for purchase at brick-and-mortar stores. If you’d like to buy Noopept, you’ll need to order it online.

We recommend ordering Noopept from PureNootropics.net as they are a reliable and reputable source for bulk nootropic powders.

Closing Thoughts

Noopept has quickly risen in popularity and has made its way into many people’s nootropic stacks due to its impressive effects, ease of its small doses, and its economical price.

Whether you are an experienced nootropic user or just getting started, Noopept may be worth your consideration.

References   [ + ]

Planning to start a new supplementation regimen? See our medical disclaimer.

This page was last updated on November 14, 2018.