The Best Nerve Growth Factor (NGF) Stack

It was once believed that after our nervous system developed, we had a set amount of nerve cells that declined with age. It was only until recently that it was discovered that our body is actually able to generate new nerve cells, including brain cells, well into our adult lives.

In 1979, Nobel Prize winner Rita Levi-Montalcini discovered Nerve Growth Factor, or NGF, a special protein that is important for the survival, maintenance, and even growth of nerve cells, including brain cells.

By maximizing the amount of NGF in our body, we are setting the stage for our body to optimize our neural network, creating stronger and more abundant synaptic connections which would result in authentic long-term improvements for brain functions including cognition and memory.

We are talking about real improvements in our brain’s physiology that may have lasting lifetime benefits.

The NGF Stack

I began to search for a nootropic stack specifically designed for promoting NGF production which should result in long-term enhancement of the brain.

You should expect some instant cognitive enhancement from this NGF nootropic stack but real lasting effects will be once your brain has had the chance to create stronger neural connections.

Expect great long-term benefits from this stack.

1x per day

  • 300 mg Uridine
    Uridine, combined with Omega 3’s from fish oil, helps protect neuron cell membranes.
  • 2 g Fish Oil
    Synchronizes with Uridine. Utilized by the majority of the brain in numerous functions.
  • 15 mg Zinc
    Regulates synaptic function between neurons.
  • 250 mg Alpha GPC
    Ensures sufficient levels of choline in the brain which is then converted to the acetylcholine neurotransmitter.
  • 3 g Lion’s Mane Mushroom
    Increases NGF production.
    View our Lion’s Mane Mushroom Article.
  • 500 mg Ashitaba
    Increases NGF production.
  • 5 mg Pregnenolone
    Increases neurogenesis.
  • 2 mg Melatonin (before bed)
    Reduces neuronal death.
  • 1 g ALCAR
    Reduces brain cell death.
  • 500 mg L-Tyrosine
    Synchronizes well with ALCAR.
  • 200 mcg NGF (eye drops)
    Optional. Effective but expensive and hard to find.

*Credit to AZabirko0901 from the Longecity Forums for the initial inspiration behind this well-thought out stack.

This is one of the most complete supplement stacks for promoting Nerve Growth Factor production with the intention of creating stronger and more abundant neural connections.

I personally take all of it except the NGF drops alongside my custom nootropic stack, and have noticed great benefits with the two combined. You won’t notice anything immediately, and it personally took my body about a week to adjust before taking these supplements started giving me very slight improvements. After a month or two, things really started ramping up. I hear around the 6 month mark, the real benefits start kicking in. We shall see.

Planning to start a new supplementation regimen? See our medical disclaimer.

  • sven

    Hi awesome site.

    I was thinking about cycling this, 5 days of a good nootropic stack (weekdays) and in the weekends use the NGF-stack. Is this a good idea?

  • Gav

    Hello – This site has some interesting advice, most of which is, IMHO, safe enough. I have tried many nootropics myself, with varying results.

    However I must point out that 100mg per day of pregnenolone is not a good idea. This is a very powerful hormone which is the precursor to many other hormones, including for example androgens (testosterone) and estrogens. Your body is a finely balanced machine, and with this you are seriously messing with it.

    If you take it at all, take much, much lower doses and with very regular breaks. Or at the very least, do the research before you take this high a dose.

    • Braintropic

      Hi Gav. This stack was originally suggested by a Longecity forum member and upon further inspection, due to your comment, the pregnenolone dose seems incorrect. We’ve modified it accordingly.

  • Abhimanyu

    Can I stack it with the study stack?

    • Braintropic

      Yes, there should be no problem with stacking them together.

      • Abhimanyu

        Thanks man!

  • Klatch, Ian

    Hi Braintropic, I’m very interested in Ashitaba. I can see the ‘Ashitaba Powder’ adverts on Ebay and Amazon… but, this is a powder… What fraction of the powder is the active ingredient ? How do we figure out how much is 10ml ? How are you taking it ? You’re drinking the tea once a day ? Twice a day ? Also, please let me know what references you have that suggest Ashitaba increase NGF by 20%.. I would be particularly interested in that. Thanks for your help. Best wishes – Klatch 🙂

    • Braintropic

      The 20% value was taken from this animal study. A common dosage is 500mg once or twice per day.

      • Bradley Jadir

        Interesting, the study there is labelled as a press release and doesnt have much detail, a bit hesitant to believe that without seeing a proper paper.

  • Diro Dirol

    Hi Braintropic,
    Can I use 5-HTP instead of Melatonin?

    • Braintropic

      In various clinical studies, melatonin has shown the ability to reduce cell death, which is it’s purpose in this particular stack. I couldn’t find evidence that 5-HTP shared that benefit.

  • Knaxta

    Hi again,

    When you stack this with the “Best Nootropic Stack”, do you also take the Alpha GPC doses from both stacks? Which is a total of 600mg (300 from this, 300 from Best Nootropic Stack)?

    Also how would you stack this with the photographic memory stack? Would you still take the total dosage of any common nootropics from both?

    • Braintropic

      If stacked with our Best Nootropic Stack I’d start out with just the same 300mg and if I had any headaches, I’d try working up to 600mg.

      If combined with the Photograhic Memory Stack, I wouldn’t double up on the items that are in both stacks (only 3g of Lion’s Mane, 2g fish oil, 300mg uridine). Also, I’d probably leave out the citicoline if already taking Alpha GPC.

      • Knaxta

        Thanks! Since I already have NALT, how about using that in place of L-Tyrosine for this stack, rather than buying L-Tyrosine which is less bio-available?

        • Braintropic

          As you said, NALT is basically a more bio-available form of L-tyrosine so I would just replace it with that.

          A low dose of pregnenolone is generally considered safe but side effects are not unheard of. A health care professional should be consulted, especially if considering long-term supplementation.

          • Knaxta

            Thank you. I noticed you’ve now changed the dosage of the pregnenolone to just 5mg opposed to upto 10mg. The link to your suggested source leads to a dosage of 10mg. Do you know where I could get a 5mg dosage from?

            Or if it’s possible, I guess halving the 10mg tablets (as long as they are tablets and not capsules) will do the trick.

          • Braintropic

            It’s always safer to stick to the lower end of the dosage ranges which is why we made the edit. The source that we linked to are in tablet form and can be halved.

          • Knaxta

            Thanks again.
            With the Galantamine from the Photographic Memory Stack, should that be taken along with the Pramiracetam during the day? Or with the Melatonin at night?

          • Braintropic

            Unless you’re taking galantamine for lucid dreaming, it should be taken during the day.

  • Jeff Simpson

    Was wondering if cycling in 25mg of DHEA in for the Pregnenolone would benefit for NGF, and for adrenals?

  • Rusquish Harowan

    Should this be taken with or without food?

  • pete

    I am new to this whole nootropic thing but from the forums I have stumbled across, 3g Lion Mane’s seems to be pretty high. I have come across one forum user who apparently experiences a withdrawal after a long term use (Sorry I can’t find the exact link).

    Any comment on this would be appreciated. Thanks!

    • Braintropic

      The single human study consisted of Lion’s Mane extract at a total daily dose of 3 g per day. They found increased scores on the cognitive function scale without any adverse affects. Of course, if you’d like to err on the side of caution, you can dose at lower amounts but we haven’t heard of reports of withdrawal.

      You can read our Lion’s Mane nootropic profile for some more info.

  • Alexander C

    Would a liquid form fish oil be as effective. I plan on taking Carlson Labs, which has a serving of 1.6g omega 3, 800mg EPA & 500mg DHA, per teaspoon (5ml). Two teaspoons seems sufficient enough to start with. Another thing, in regards to the lions mane mushroom, I’ve read elsewhere that it’s best used in extract powder form, as its more potent. I prefer to order in capsule form, but should I stick to one that is a water extract powder form and is polyssachirades of importance?

    • Braintropic

      The Carlson Labs Fish Oil appears to be a high-quality choice and there’s no reason it wouldn’t be as effective as encapsulated oils.

      For Lion’s Mane, to keep dosage reasonable, the extract is what you’ll want. For increased NGF levels, there is evidence that ethanol extraction (vs. water extraction) is more effective. The polysaccharide content contains a lot of the beneficial components as well. A standard extract will be 10:1 ratio with 30% polysaccharide content.

  • Bryan

    How often should the ‘Best Nootropic Stack’ and ‘NFG Stack’ be taken?

    • Braintropic

      They were designed for daily dosing due to their potential for long-term benefits.

  • Bryan

    What about tolerance issues with the sulbutiamine?

    • Braintropic

      For some people, tolerance to sulbutiamine can develop rather quickly so it is recommended to take it only as needed and not every single day.

  • Name

    If someone didn’t mind spending the extra cash, where would they be able to find ngf eye drops?

  • Name

    At about $200 a day that is. I might try it. I might have to research this source a little more. It seems like the NGF needs to be purchased and mixed with some kind of eye drop solution. Not impossible, just needs a little more research. The thing that discourages me to buy is that they also sell NGF for mice. Not saying that it will happen, but what if they accidentally ship the mice NGF. Ooops. Highly unlikely but still possible.

  • Name

    Thanks for the links. I’m unable to add the NGF to my cart. Is there another source?

  • Vincent

    If I were to take the Uridine sublingually, should I take the rest of the supplements beforehand or after?

  • Bryan

    I’ve heard krill oil is more effective. What is you’re opinion?

    • Braintropic

      The benefits of fish oil have been studied extensively whereas the research on krill oil is still quite limited. Krill oil does appear to have great properties, though. Whichever you choose, make sure you stick to high-quality sources.

  • Bryan

    If the dose for alpha gpc is 300mg and I am using alpha gpc 50%. Do I make my dose 600mg?

    • Braintropic

      Yes, that’s right.

  • Thomas

    Can you estimate the cost to combine this stack with the “photographic memory stack”, and the “Best Nootropic stack”?

  • wiz

    if you took this stack and the photographic memory stack for 6 months combined with brain training or something then stopped taking them would the improvements be long lasting? if so what nootropics/brain training are recommended for that and does age matter with nootropics if i am 19 not looking for a stimulatory effect as much as long lasting improvements thanks

  • MInh D Nguyen

    BrainTropic, can I add bacopa and Ashwagandha to the stack? Is it redundant to do so?

    • MInh D Nguyen

      Also what about Ginkgo? Is it ok to add to the stack?

  • John

    Where’d you go? Can you do some updates?

  • john

    Do you have an update here? What are you currently trying?

  • Matt

    What is the recommended way to take this stack? All together in the morning (saving the Melatonin for bed) or staggered throughout the day? With food or on an empty stomach?