Centrophenoxine, also known as meclofenoxate or Lucidril, is a well-known and respected nootropic that has been proven over five decades of use and rigorous clinical testing. It’s a powerful nootropic and memory booster in its own right, and it’s also an excellent choline source for use in combination with other nootropics.
Developed in 1959 by scientists at the French National Scientific Research Center, centrophenoxine was created as a treatment for Alzheimer’s disease and other forms of cerebral insufficiency and age-related cognitive decline. While it is still prescribed for the treatment of age-related memory loss in Europe, it is available over the counter as a dietary supplement in the US and is most frequently used for its nootropic or cognitive enhancement properties.
Centrophenoxine is classified as a cholinergic, a substance that delivers or enhances the action of choline. It’s this cholinergic capability that makes it an efficient and effective nootropic on its own and a powerful potentiator when used in combination with other nootropics, particularly the racetams.
Choline is the precursor of the neurotransmitter acetylcholine, which is strongly associated with many aspects of cognitive function. Nootropics such as piracetam, pramiracetam, oxiracetam, aniracetam, and others which act by stimulating the production and release of acetylcholine draw heavily on the brain’s choline supplies. Since they can only achieve optimal results when sufficient choline is available, users are advised to include a good choline source like centrophenoxine in every racetam stack.
Centrophenoxine has also been shown to act as an effective antioxidant and neuroprotectant, reversing the destructive effects of toxins and free radicals in the brain and effectively slowing cognitive decline.
It may also act as a mild stimulant and antidepressant.
Benefits and Effects
Centrophenoxine offers a wide range of benefits for both brain and body:
- Better Memory – Centrophenoxine is best known for its considerable abilities as a memory booster. Its primary action is providing additional choline and enabling the production of acetylcholine, the neurotransmitter that is most closely tied to cognitive function in general and memory in particular.
- Enhanced Fluid Intelligence – Centrophenoxine can enhance fluid intelligence, or the ability to solve problems without relying on acquired knowledge.
- Improved Overall Brain Function – Centrophenoxine is considered a neuro energizer because it stimulates glucose uptake, oxygen consumption, and carbon dioxide production. The additional oxygen and glucose add to its nootropic effects, making learning easier, thoughts clearer, and all of the brain’s functions more efficient.
- Increased Energy – Many users find that centrophenoxine has a mild stimulant effect. While it energizes without creating the jittery feelings that amphetamines or other stimulants cause, its energy boost is enough to disrupt regular sleep patterns if taken late in the day.
- Anti-aging – Research shows that centrophenoxine is an aggressive free radical scavenger and powerful antioxidant that protects the brain from age-related deterioration, flushes out toxins, and repairs damaged cells.
- Mood and Motivation – Users report that centrophenoxine has a strong motivating and mood-improving effect, acting as a mild but noticeable anti-depressant.
How it Works
Centrophenoxine is a combination of PCPA (parachlorphenoxyacetic) and a synthetic version of DMAE (dimethylaminoethanol) that has been modified to improve absorption and enhance its ability to cross the blood-brain barrier. It is a fat-soluble compound that is metabolized in the liver.
Though centrophenoxine has been the subject of decades of research, its precise mechanisms of action are still not entirely clear. While it is known to cross the blood-brain barrier and ultimately increase the amount of acetylcholine in the synaptic vesicles, the exact method by which the process takes place remains a matter of speculation. Some researchers theorize that it works by converting into an intermediary phospholipid which is then used to make acetylcholine, while others believe it breaks down into choline in the brain and then is converted to acetylcholine.
But though the exact mechanism of action is not known, it is clear that centrophenoxine is a net cholinergic that increases production of acetylcholine, the neurotransmitter most strongly associated with memory and general cognitive acuity. This function is the primary means by which centrophenoxine acts as a nootropic, but it enhances cognition in other ways as well.
Centrophenoxine has proven anti-aging as well as nootropic properties. It is an effective antioxidant capable of flushing out toxins that build up in cells as we age. It has been shown to reduce or even eliminate the buildup of lipofuscin, a waste material present in aging cells, and it is believed to halt and perhaps even reverse the cellular potassium buildup that is associated with age-related cognitive decline.
A typical dose when taking as a nootropic, either on its own or in a stack, is 250 mg. A cumulative daily dosage ranging from 500-1000 mg is considered both safe and effective for most healthy adults interested in centrophenoxine’s cognitive and nootropic benefits. Higher doses may be required to maximize its anti-aging effects, but it is advisable to consult a medical professional before exceeding the recommended daily dosage.
As with all supplements, it is best to start with the lowest possible effective dose and build gradually as needed.
Because centrophenoxine is fat-soluble, it is best taken with food. Its mild stimulant effect could potentially interrupt sleep patterns if taken late in the day.
Centrophenoxine is an outstanding choline source that works extremely well with other nootropics, particularly the racetams.
Centrophenoxine and Aniracetam Stack
Here’s an example of a centrophenoxine stack that includes the popular racetam aniracetam to boost memory retention, mood, creativity, while reducing anxiety.
Centrophenoxine and Noopept Stack
Here’s an example of a centrophenoxine stack that includes the popular nootropic Noopept to improve memory and learning, while providing neuroprotective properties.
Review our article on how to create a nootropic stack for a general primer on basic combinations, ratios, and tips on designing your own nootropic stack.
Centrophenoxine is safe and nontoxic at every level of dosage and is very well tolerated. However, some users have experienced mild and minor side effects, including nausea, headache, gastrointestinal issues, and sleeplessness. In most cases, the side effects were associated with high doses and reducing the cumulative daily dosage eliminated the unwanted side effects.
Where to Buy
Centrophenoxine can be purchased online via Amazon or specialized nootropics vendors.
Buying from Amazon is convenient and available in capsule form such as Double Wood Centrophenoxine Capsules.
Alternatively, you can buy centrophenoxine from a specialized nootropic vendor such as PureNootropics.net.
Centrophenoxine is a safe, effective nootropic supplement that can significantly boost memory, learning ability, fluid intelligence, and concentration. It is also a known anti-aging supplement capable of flushing toxins from cells and halting, or perhaps even reversing, age-related cellular damage.
For nootropic users, centrophenoxine is an outstanding source of choline that works exceptionally well with other supplements like the racetams, which put heavy demand on the brain’s choline supplies.
Centrophenoxine is an affordable, readily available supplement with a long track record of success. Whether you’re interested in a powerful memory booster, an anti-aging supplement, or a high-quality choline source to combine with other nootropics, this could be a supplement worth taking.
References [ + ]
|1.||^||Richter K. Treatment results with Cerutil in age-related cerebral insufficiency in general medicine. (1983)|
|2.||^||Nandy K. Centrophenoxine: effects on aging mammalian brain. (1978)|
|3.||^||Glees P, et al. Centrophenoxin-induced dissolution and removal of lipofuscin. An electron microscopic study. (1975)|
Planning to start a new supplementation regimen? See our medical disclaimer.